BackgroundMalignant melanoma is an extremely aggressive and metastatic cancer, and highly resistant to conventional therapies.Signal transducer and activator of transcription 3 (STAT3) signaling promotes melanoma development and progression, which has been validated as an effective target in melanoma treatment.Natural naphthoquinone shikonin is rep
Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes.On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the
Stranded driftwood feedstocks may represent, after pretreatment with steam explosion and enzymatic hydrolysis, a cheap C-source for producing biochemicals and biofuels using oleaginous yeasts.The hydrolysis was optimized using a response surface methodology (RSM).The solid loading (SL) and the dosage of enzyme cocktail (ED) were variated following
This article examines the literature relating to the organisation of the Republican Calming State and the State in the rebel area during the Spanish Civil War.We identify in both cases the works relating to the organs of the State at the Baby international, national and local levels.Literature concerning official repression in the Republican and re